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KMID : 1134820060350091166
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Journal of the Korean Society of Food Science and Nutrition
2006 Volume.35 No. 9 p.1166 ~ p.1171
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Effects of Silk Protein Hydrolysates on Blood Glucose in C57BL/KsJ db/db Mice
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Shin Mi-Jin
Park Min-Jeong
Youn Myung-Sub
Lee Young-Sook
Nam Moon-Suk
Park In-Sun
Jeong Yoon-Hwa
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Abstract
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This study was performed to investigate the effect of silk protein hydrolysates on blood glucose in diabetic mice (C57BL/KsJ db/db). The silk protein hydrolysates hydrolyzed by protease contains 87.52% of peptides of which molecular weight was below 2,000 dalton. The content of free amino acids was 14.80 g/100 g silk protein hydrolysates and major free amino acids were Pro, Thr, Arg and Ala. Silk protein hydrolysates were administered to the animals for 9 weeks at doses of 0.2, 0.5% and 0.8% solution. The body weight increase in the 0.5 and 0.8% fed groups were higher than control group. Food and water intake in the silk protein hydrolysates fed groups were lower than control group. The weight of liver was not different among groups, while the weight of kidney in control group was higher than silk protein hydrolysates fed groups. The blood glucose level in silk protein hydrolysates fed groups was lower than control group. In the glucose tolerance test, the blood glucose level in control group was the highest at 15 minutes after glucose injection while those in silk protein hydrolysates fed groups were the highest at 30 minutes. Results in this study suggest that silk protein hydrolysates show hypoglycemic effect in C57BL/KsJ db/db mice.
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KEYWORD
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diabetic mice, silk protein hydrolysates, blood glucose
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